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与压力相关的基因调节:孤立和连接的个体有区别吗?
Yvonne S Yang1, Jonathan K Wynn2, Steve Cole3
1VISN22 Mental Illness Research, Education and Clinical Center, VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Los Angeles, CA, 90073, USA; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA, 90095, USA.
Brain, behavior, and immunity
|June 19, 2024
概括
社会隔离和孤独会对健康产生严重的影响. 这项研究发现,客观的社会隔离可能不会导致与孤独一样的负面健康结果,而社会互动对孤立的个人来说可能更有压力.
科学领域:
- 心理神经免疫学 心理神经免疫学
- 社会神经科学 社会神经科学
- 基因组学就是基因组学.
背景情况:
- 社会隔离和孤独 (社会断开) 与不良健康结果有关,包括寿命缩短和心脏病风险增加.
- 了解将社会脱节与负面健康联系起来的生物机制至关重要.
- 以前的研究发现,社会动机和能力是影响社会隔离和孤独的因素.
研究的目的:
- 研究社会隔离和联系对免疫基因表达的影响.
- 检查社会动机和能力如何影响社会联系状态和免疫反应之间的关系.
主要方法:
- 通过在线广告招募了102名参与者,这些广告针对的是社会上孤立的个人和一般参与者.
- 根据广告响应,将参与者分为"孤立"和"连接",收集关于孤立,孤独,社会动机和能力的数据.
- 评估了使用全基因组转录概况的保护转录对逆境反应 (CTRA) 压力基因调节程序.
主要成果:
- 在连接和孤立的群体之间,CTRA基因表达模式是逆转的.
- 社会隔离与有联系的个体中较高的CTRA相关,但与孤立的个体中较低的CTRA相关.
- 社交方法/避免在连接群体和孤立群体中不同地影响了CTRA水平;社交能力的影响最小.
结论:
- 客观的社会隔离可能不会带来以前基于孤独研究的假设相同的负面健康后果.
- 对于一些社会隔离的个人来说,社会互动本身可能比社会隔离更有生理压力.
- 研究结果表明,社会背景,个人社会倾向和免疫系统反应之间存在复杂的相互作用.
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