在流行率较低的地区发生了社区的甲素耐药黄金葡萄球菌疫情
Katherine L Bellis1, Oshani M Dissanayake2, Ewan M Harrison1
1Department of Medicine, University of Cambridge, Hills Rd, Cambridge, UK; Wellcome Sanger Institute, Parasites and Microbes, Hinxton, Saffron Walden, UK.
概括
在全球范围内,即使在流行率较低的地区,社区获得的甲素耐药黄金葡萄球菌 (CA-MRSA) 也在增加. 了解传播因素和实施综合监测是控制的关键.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 微生物学
- 流行病学 流行病学
背景情况:
- 社区获得的抗甲林金色葡萄球菌 (CA-MRSA) 构成了日益严重的全球健康挑战,特别是在历史上流行率较低的地区.
- 尽管医院发病的MRSA病例减少,但社区发病的MRSA (CO-MRSA) 病例在全球范围内正在增加,需要了解导致因素和复发风险.
研究的目的:
- 在低流行环境中审查CA-MRSA疫情的特征.
- 为了确定推动CO-MRSA的增加的因素.
- 为公共卫生政策和未来的研究方向提供信息.
主要方法:
- 在PubMed,EMBASE和谷歌学者中进行全面的文献搜索.
- 关键词包括"传播"",获取"",社区获取"",MRSA"",CA-MRSA"",低流行"",基因组"",疫情"",殖民化"和"运输".
- 针对有限的证据和排除非英语文章的有针对性的搜索.
主要成果:
- 在定义低患病率地区和确定社区获取风险因素 (医疗保健,旅行,畜牧业,环境) 方面存在挑战.
- 基因组监测对于识别疫情菌株和了解传播动态至关重要.
- 有效的控制需要强有力的公共卫生政策和综合监测战略.
结论:
- CO-MRSA的传播是复杂的,需要在低患病率地区采取多方面的方法.
- 建议对医院发病,社区发病和牲畜相关的MRSA进行综合监测,并借鉴成功的模型.
- 全球合作,常规基因组监测和抗菌药物管理对于打击CO-MRSA和更广泛的抗菌药物耐药性至关重要.
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