在猪中增强系统性病毒特异性T淋巴细胞反应,补充了藻类衍生的β-葡萄糖
Sh B Chuaychu1, C Sirisereewan2, N Techakriengkrai3
1International Graduate Program of Veterinary Science and Technology, Faculty of Veterinary Science, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.
Veterinary journal (London, England : 1997)
|June 19, 2024
概括
来自藻类的β-葡萄糖补充剂通过促进病毒特异性T淋巴细胞和抗体反应,增强了猪的抗病毒免疫力. 这种免疫调节可能会改善猪的抗病能力,尽管没有观察到生长性能的变化.
科学领域:
- 动物科学动物科学
- 免疫学 免疫学 免疫学
- 兽医医学 兽医医学 兽医医学
背景情况:
- 来自藻类的β-葡萄糖是一种常见的猪料添加剂,旨在改善生长和免疫力.
- 藻类衍生的β-葡萄糖对猪抗原特异性免疫反应的特定影响需要进一步研究.
研究的目的:
- 评估藻类衍生的β-葡萄糖对猪生长性能,抗体产生和T淋巴细胞反应的影响.
- 确定藻类衍生的β-葡萄糖作为对猪病毒感染的免疫调节剂的潜力.
主要方法:
- 每次治疗的112只小猪被分配到对照,100微克/β-葡萄糖 (BG100) 或200微克/β-葡萄糖 (BG200) 组.
- 评估了生长性能,经典猪瘟病毒 (CSFV) 特定抗体标位和T淋巴细胞反应.
- 评估猪生殖和呼吸系统综合征病毒 (PRRSV) 特定的干扰素- (IFN-γ) 产生T淋巴细胞和疫苗诱导的病毒性病.
主要成果:
- 两组之间没有观察到生长表现的显著差异.
- 补充β-葡萄糖增加了CSFV特异性T淋巴细胞和中和抗体标位.
- 增强了PRRSV特定的IFN-γ产生T淋巴细胞 (CD4+,CD8+,CD4+CD8+) 和减少了补充猪的MLV病毒性病.
结论:
- 来自藻类的β-葡萄糖有效地增强了猪的抗原特异性免疫反应,特别是抗病毒免疫力.
- 补充剂调节T淋巴细胞亚群和抗体产生,表明有可能改善疾病抵抗力.
- 来自藻类的β-葡萄糖显示出作为用于猪健康管理的免疫调节性料添加剂的前景.
相关概念视频
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