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Updated: Jul 5, 2026

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes
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Published on: June 3, 2014

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通过准其表皮生长因子类1域中的2个独特补丁,可以通过纳米体防止XII因子接触激活

Rowan Frunt1, Hinde El Otmani1, Simone Smits1

  • 1Central Diagnostic Laboratory Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Journal of thrombosis and haemostasis : JTH
|June 19, 2024
PubMed
概括

研究人员在因子XII的EGF-1域中发现了两个带电补丁,这对表面结合和接触激活至关重要. 用抗体向这些贴片可以预防血栓形成,特别是由医疗设备引起的血栓形成.

关键词:
绑定站点 绑定站点血液凝固 血液凝固一个XII因子XII因子.卡利克里恩基宁系统一个单域抗体的抗体.

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