胃肠道的临床病理特征 朗格汉斯细胞细胞瘤
Shaomin Hu1, Rondell P Graham2, Won-Tak Choi3
1Cleveland Clinic, Department of Pathology, Cleveland, Ohio.
概括
胃肠道中的朗格汉斯细胞囊细胞形成 (LCH) 是罕见的. 成年人单系统性肠道肠道肠道血管疾病的预后很好,而多系统性肠道血管疾病在任何年龄段都表明不利的结果.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 胃肠道 (GI) 通过兰格汉斯细胞囊细胞症 (LCH) 的参与是不常见的.
- 胃肠道LCH的临床病理学特征主要来自病例报告和小系列.
研究的目的:
- 在儿童和成人患者队列中划分GI LCH的临床病理特征.
- 基于疾病程度 (单系统与多系统) 和患者年龄的结果进行比较.
主要方法:
- 对47名患有胃肠道LCH的患者进行了回顾性审查.
- 对血素和素和免疫组织化学 (CD1a,S100,Langerin) 染色片进行分析.
- 临床病理学发现与人口统计数据和临床结果的相关性.
主要成果:
- 儿科GI LCH (n=8) 始终是多系统的,有症状的,非多聚体的,多焦点的和透性的,预后不好.
- 成人单系统肠道肠道瘤 (n=25) 往往是偶然的,通常是单独的结直肠多,具有非透的生长和良好的预后.
- 成人多系统肠道肠道肠道肠道肠道链路 (n=14) 与儿科肠道链路具有共同的特征,包括症状表现,非结肠直肠参与,多焦点病变,非多聚体形态,透生长以及更高的持续性疾病率.
结论:
- 患有单系统性胃肠道LCH的成年人有很好的预后.
- 多系统的LCH,无论年龄如何,都带有不利的预后.
- 关键的高风险特征的GI LCH包括儿科年龄,GI症状,非结肠直肠的参与,多焦点性疾病,非多聚质性病变和透性生长.
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