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设计,优化和表征阿托瓦斯塔丁加载的基托基聚电解质复合物基于纳米颗粒的透皮贴片

Pravin Patil¹, Ankit Vankani¹, Krutika Sawant¹

¹Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara 390001, Gujarat, India.

International journal of biological macromolecules

|June 19, 2024

概括

这项研究开发了阿托瓦斯塔丁 (ATO) 装载的基托基聚电解质复合纳米颗粒 (PECN) 透皮贴片. 与口服药片相比,该新型贴片显著提高了ATO的皮肤透性和生物可用性.

科学领域:

制药科学制药科学
纳米技术纳米技术
药物输送系统药物输送系统

背景情况:

阿托瓦斯塔丁 (ATO) 的生物可用性较差,需要先进的输送系统.
基索基聚电解质复合纳米颗粒 (PECN) 提供了改善药物输送的潜力.
通过皮肤贴片提供一种非侵入性的药物给药途径.

研究的目的:

为了开发和评估阿托瓦斯塔丁 (ATO) 装载的基托基聚电解质复合纳米颗粒 (PECN) 纳入透皮贴片.
通过一种新的通过皮肤递送系统,提高ATO的皮肤透性和生物可用性.

主要方法:

用ATO装载的PECN使用离子凝方法制备,并使用Box-Behnken设计进行优化.
进行了物理化学特征,体外,体外,细胞系和稳定性研究.
优化的ATO-PECN被纳入皮肤贴片中,随后进行全面评估.

主要成果:

优化的ATO-PECN的粒子大小为219.2 ± 5.98nm,捕获率为82.68 ± 2.63%和+25.41 ± 3.29 mV的泽塔电位.
与ATO悬浮剂相比,ATO-PECN表现出持续的药物释放,增强的皮肤透性和增加的细胞透性.
通过皮肤贴片显示出优异的ex vivo皮肤透性和显著改善的体内药理动力学参数,证实了增强的生物可用性.

结论:

开发的阿托瓦斯塔丁载的PECN皮肤贴是一种有前途的药物输送系统.
这种新的系统有效地提高了阿托瓦斯塔丁等生物可用性较差的药物的生物可用性.
这项研究突出了基托桑基PECN在先进的皮肤过体药物递送应用中的潜力.

关键词:

一个阿托尔瓦斯塔丁.生物可用性生物可用性优化优化优化优化复杂的多电解质复合物通过皮肤通过皮肤.

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