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Updated: May 12, 2026

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双重封装和顺序释放西斯普拉丁和维生素E从大豆多糖和β-环氧化生物粘合水凝纳米颗粒

Mohamed Eid¹, Jingsong Zhu², Muhammad Asif Ismail³

¹College of Food Science and Technology, Huazhong Agricultural University, 1st Shizishan Road, Wuhan, Hubei 430070, China; Key Laboratory of Environment Correlative Dietology, Huazhong Agricultural University, Ministry of Education, 1st Shizishan Road, Wuhan, Hubei 430070, China; Department of Biochemistry, Faculty of Agriculture, Benha University, Moshtohor, 13736 Qaliuobia, Egypt.

International journal of biological macromolecules

|June 19, 2024

概括

化学交联的水凝纳米粒子 (HGNPs) 已开发用于双重药物输送. 这些pH-热敏的HGNP成功地加载了西斯和维生素E,增强了它们的控制释放和生物可用性.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
药物输送系统药物输送系统

背景情况:

化学交联的水凝纳米粒子 (HGNPs) 在药物输送方面表现优异,相比于物理交联的纳米粒子.
开发先进的药物输送系统对于提高治疗疗效和患者治疗结果至关重要.

研究的目的:

创建pH-热双响应,生物粘合性HGNP,用于复合和控制释放西斯 (CDDP) 和维生素E (VE).
通过使用这些新型HGNP来提高CDDP和VE的生物可用性和体内循环时间.

主要方法:

通过与大豆多糖化合物 (SSPS) 的化学结合和通过与HGNP中的β-环氧 (β-CD) 的宿主-客人相互作用的VE通过CDDP的双复合.
使用FTIR,XRD,XPS和zeta潜力的HGNP的表征.
在不同的pH值和温度下进行体外释放研究,以及体内循环时间评估.

主要成果:

高GNP 呈现出均的大小分布 (约90 nm) 和确认的结合.
在pH 1.2下,CDDP的累积释放率高 (98%),在pH 7.4.4下释放率显著降低 (<45%).
与生理温度 (37°C,42°C) 相比,在较低的温度 (25°C) 中药物释放速度较慢.
提高了CDDP (15 wt%) 和VE (11.32 wt%) 的整合效率.
(VE/CDDP) 载荷的HGNP在体内循环时间比自由药物更长.

结论:

开发的pH-热双响应的HGNP对于双重药物复合和受控释放是有效的.
高GNP系统显著改善了CDDP和VE的生物可用性和循环概况.
这种方法对先进的组合疗法和改进的药物输送应用有希望.

关键词:

西斯普拉丁 (Cisplatin) 是一种累积释放量是一个累积释放量.双响应式双响应式纳米气凝的使用方法维生素E 维生素E 是一种维生素.

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