肠道微生物组的组成和功能会影响对含有银-寡糖糖类的乳制品的反应,以改善成年人睡眠质量
G A M Kortman1, E R Hester1, A Schaafsma2
1NIZO food research B.V., 6718 ZB Ede, the Netherlands.
Beneficial microbes
|June 19, 2024
概括
一种基于乳制品的产品通过调节肠道微生物群来改善睡眠质量. 受访者表现出明显的基线肠道细菌,包括较低的Bifidobacterium longum和Bifidobacterium adolescentis,以及较高的Faecalibacterium prausnitzii.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 睡眠医学 睡眠医学
背景情况:
- 饮食显著影响睡眠质量和持续时间,通过微生物群-肠-大脑轴影响肠道微生物群的组成和功能.
- 调节肠道微生物组是提高睡眠质量的潜在策略.
研究的目的:
- 评估乳制品 (DP) 对肠道微生物群组成和功能对健康成年人中适度睡眠障碍的影响.
- 确定肠道微生物群,睡眠质量和治疗反应之间的关联.
主要方法:
- 一项为期3周的干预研究,涉及67名健康受试者,他们有中度睡眠障碍.
- 枪元基因组学测序便DNA以分析微生物群的分类学和功能.
- 应用肠脑模块 (GBM) 数据库来分析可能与大脑相互作用的微生物功能.
主要成果:
- DP治疗对肠道微生物群组成产生了中度的区分作用,特别是减少了Pseudomonas resinovorans,Flintibacter sp. KGM00164, 肠道中的黄油产物, 和 黄裂物 .
- 在响应者和非响应者之间观察到基线微生物群组成的显著差异.
- 与未响应者相比,响应者表现出较低的Bifidobacterium longum和Bifidobacterium adolescentis的相对丰度,以及较高的Faecalibacterium prausnitzii的相对丰度.
结论:
- 该研究提供了关于乳制品产品改善睡眠的有效性和机制的见解.
- 研究结果表明,基线肠道微生物群组成,特别是Bifidobacterium和Faecalibacterium的丰度,可以预测对睡眠营养干预措施的反应.
- 这项研究支持未来开发有针对性的营养策略,通过肠道微生物组调节来提高睡眠质量.
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