支气管肺功能障碍症严重程度与其风险因素及其长期结果之间的关联在三个定义中:一个历史的队列研究
Trixie A Katz1,2, Anton H van Kaam2,3, Nicolaas P A Zuithoff4
1Neonatology, Emma Children's Hospital UMC, Amsterdam, The Netherlands.
概括
三种支气管肺功能失调症 (BPD) 定义的严重程度分类预测了早产婴儿的神经发育和呼吸系统结果的差异. 在2001年NIH,2018年NIH和2019年詹森标准之间没有发现显著差异.
科学领域:
- 新生儿科学 新生儿科学
- 儿科肺病学 儿科肺病学
- 发育儿科 发育儿科
背景情况:
- 支气管肺功能障碍症 (BPD) 是一种慢性肺部疾病,会影响早产婴儿.
- 准确的BPD严重程度分类对于预测长期结果至关重要.
- 现有的BPD定义已经发展,需要对其预测能力进行比较.
研究的目的:
- 从三个BPD定义 (2001年NIH,2018年NIH,2019年詹森) 进行严重程度类别的关联与长期神经发育和呼吸系统结果的比较.
- 评估这些BPD定义在2岁和5岁时对不良结果的预测准确性.
- 为了确定与严重程度有序关系的BPD风险因素.
主要方法:
- 在2009-2015年间,单一中心对早产婴儿出生<30周GA的历史队列研究.
- 追溯收集关于围产期特征,人口统计和并发症的数据.
- 后勤回归和布莱尔评分用于评估BPD严重程度和结果 (神经发育障碍/晚期死亡,呼吸系统发病率) 之间的关联.
主要成果:
- 584名早产婴儿使用三个BPD定义进行了分类.
- 没有一个定义显示出明显的顺序式增加的不良结果的风险与严重程度的增加.
- 呼吸干预显示了与BPD严重程度的顺序关系,与GA不同,出生体重或GA状态小.
结论:
- 三种BPD定义的严重程度分类在预测神经发育和呼吸道疾病的准确性较低.
- 在2001年NIH,2018年NIH和2019年詹森BPD定义中没有观察到预测准确性的显著差异.
- 目前的BPD严重程度分类可能需要改进,以更好地预测婴儿长期结果.
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