自身免疫性疾病与冠状动脉样硬化严重程度和缺血事件的关联
Martin Bødtker Mortensen1, Jesper Møller Jensen2, Niels Peter Rønnow Sand3
1Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Journal of the American College of Cardiology
|June 19, 2024
概括
自身免疫性疾病增加了动脉样硬化心血管疾病 (ASCVD) 和冠状动脉样硬化的风险. 控制传统的心血管风险因素对于改善这些患者的治疗结果至关重要.
科学领域:
- 心血管医学 心血管医学
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 自身免疫性疾病与动脉样硬化心血管疾病 (ASCVD) 的风险增加有关.
- 在这种情况下,传统风险因素的机制和影响尚未完全理解.
研究的目的:
- 调查自身免疫性疾病和冠状动脉样硬化之间的独立关联.
- 确定传统的心血管风险因素是否调节自免疫性疾病患者的ASCVD风险.
主要方法:
- 分析了来自西丹麦心脏登记处的85,512名患者,使用冠状动脉计算机断层扫描血管学.
- 对18种自身免疫性疾病的诊断评估.
- 为冠状动脉样硬化而调整的几率比率 (aOR) 和为ASCVD事件调整的危险比率 (aHR) 的计算.
主要成果:
- 自身免疫性疾病独立地与较高的冠状动脉样硬化负担有关,包括任何斑块,任何冠状动脉化 (CAC) 和严重的CAC.
- 患有自身免疫性疾病的患者患ASCVD事件的风险增加了46%.
- 在自身免疫患者中,有利的心血管风险因子概况显著降低了ASCVD风险.
结论:
- 自免疫性疾病独立地与冠状动脉样硬化和ASCVD风险增加有关.
- 传统的心血管风险因素加剧了风险,这表明动脉动脉生成加速.
- 对心血管风险因素的有效管理对于改善自身免疫性疾病患者的预后至关重要.
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