适应性癌症治疗在生成性人工智能时代
1Ted Rogers School of Information Technology Management, Toronto Metropolitan University, Toronto, ON, Canada.
Cancer control : journal of the Moffitt Cancer Center
|June 19, 2024
概括
适应性癌症治疗需要实时预测治疗反应. 这项研究建议使用生成人工智能 (AI),特别是生成预训练变压器 (GPT),与适应性治疗相结合,以预测疾病进展,以改善癌症护理.
科学领域:
- 在瘤学瘤学.
- 人工智能的人工智能
- 计算生物学 计算生物学
背景情况:
- 治疗耐药性对开发有效的癌症治疗提出了重大挑战.
- 适应性癌症治疗,利用药物组合,调节时间和剂量,是管理癌症动态性质的有希望的策略.
- 适应性治疗的临床成功受到缺乏实时治疗反应预测能力的阻碍.
研究的目的:
- 探索生成性人工智能 (AI) 在预测癌症治疗反应方面的潜力.
- 提出一个综合模型,将生成预训练变压器 (GPT) 与自适应性癌症治疗相结合.
- 解决在适应性治疗方案中对实时疾病进展预测的关键需求.
主要方法:
- 在自适应性癌症治疗的闭环系统中概念化生成预训练变压器 (GPT) 的集成模型.
- 利用临床,分子和放射学数据来训练AI预测模型.
- 讨论与实施人工智能驱动的适应性治疗策略相关的挑战.
主要成果:
- 生成型人工智能,特别是GPT,显示了学习治疗反应的复杂预测模型的潜力.
- 拟议的模型旨在通过将GPT与适应性治疗方案相结合来预测疾病进展轨迹.
- 确定了在临床瘤学中实现人工智能驱动的适应性治疗的关键挑战.
结论:
- 生成型人工智能为克服当前适应性癌症治疗方法的局限性提供了一个有希望的途径.
- 使用人工智能对治疗反应的实时预测对于适应性治疗的成功临床实施至关重要.
- 需要进一步的研究和开发,以有效地将人工智能集成到瘤学中,以进行个性化癌症治疗.
相关概念视频
Tumor Immunotherapy
511
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
511
Non-equilibrium in the Cell
4.4K
An important concept in studying metabolism and energy is that of chemical equilibrium. Most chemical reactions are reversible. They can proceed in both directions, releasing energy into their environment in one direction, and absorbing it from the environment in the other direction. The same is true for the chemical reactions involved in cell metabolism, such as the breaking down and building up of proteins into and from individual amino acids, respectively. Reactants within a closed system...
4.4K
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Cancer Vaccines
352
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
352
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Gene Therapy
25.4K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
25.4K


