在精神分裂症早期阶段,皮质厚度的补偿性加厚
Yujue Wang1, Lejia Fan1,2, Ying He1,3,4,5,6
1Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Furong District No. 139 Renmin Road, Changsha 410011, Hunan, China.
Cerebral cortex (New York, N.Y. : 1991)
|June 19, 2024
概括
精神分裂症是一种精神分裂症.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 在早期精神分裂症中注意到大脑结构异常.
- 关联皮层变化,炎症和症状的潜在机制尚不清楚.
研究的目的:
- 研究皮质异常,代谢物水平,炎症和精神分裂症的临床症状之间的关系.
- 为了区分这些因素与健康对照组,超高精神病风险的个体和第一发精神分裂症患者.
主要方法:
- 招募了51名未经药物治疗的第一发精神分裂症 (FES) 患者,51名超高风险精神病患者 (UHR) 和51名健康对照人 (HC).
- 评估灰质体积 (GMV),皮质厚度 (CT),代谢物度和炎症标志物.
- 在UHR转换器 (UHR-C),UHR非转换器 (UHR-NC),FES和HC组中比较了这些措施.
主要成果:
- 在UHR-C组中,右侧尾皮质和右中间轨道前皮质 (rMOF) 的CT增加.
- 在FES组,右侧状皮质的CT显着减少.
- 在UHR-C组中发现IL-6水平升高;IL-17预测了状CT,IL-4/IL-17预测了rMOFCT.
结论:
- 在UHR-C中CT的增加可能与炎症反应和补偿机制有关.
- 皮层变化可能反映出神经毒性影响随着精神分裂症的进展.
- 炎症在精神病发育期间的皮质变化中起作用.
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