确定目标人群,以与决策者的需求保持一致
Jennifer L Lund1, Anthony A Matthews2
1Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
American journal of epidemiology
|June 19, 2024
概括
随机试验提供了平均治疗效果,但决策者需要针对特定人群量身定制的证据. 研究人员应将试验设计与决策者对相关现实数据和分析的需求相协调.
科学领域:
- 临床试验 临床试验
- 药理流行病学 药理流行病学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 随机试验 (RCT) 评估了被注册参与者的平均治疗效果.
- 决策者需要适用于其特定目标人群的证据,这些人群往往不同于RCT人群.
研究的目的:
- 引导研究人员将证据生成与决策者需求相协调.
- 确定决策者群体及其针对特定卫生干预的目标人群.
- 为了确定什么时候单靠RCT就足够,而什么时候需要现实世界的数据.
主要方法:
- 概述了5个主要的决策者群体:政策制定者,支付者,购买者,提供者和患者.
- 特定的目标人群,以测量β-阻断剂在心肌梗塞后的有效性,并保留喷射分数.
- 概括了应用RCT结果的场景和建议的分析方法.
主要成果:
- 随着试验和目标人群之间的对齐,RCT的概括性会有所不同.
- 现实世界的数据和补充分析通常是必要的,以满足决策者的特定需求.
- 需要一个结构化的方法来弥合试验证据和政策应用之间的差距.
结论:
- 研究人员必须在研究过程的早期积极确定决策者及其目标人群.
- 将证据生成量身定制为特定的决策者背景,提高了研究结果的有用性.
- 将RCT与现实数据分析相结合,对于为各种医疗保健决策提供信息至关重要.
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