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纤维类型的益生菌和妇科和乳腺癌的风险:PrebiotiCa研究

Federica Turati¹, Giovanna Esposito¹, Federica Concina²

¹Department of Clinical Sciences and Community Health, University of Milan, Dipartimento di Eccellenza 2023-2027, Milan, Italy.

American journal of epidemiology

|June 19, 2024

概括

益生菌纤维摄入量显示与妇科癌症的混合关联. 尼糖摄入量与乳腺癌和卵巢癌风险增加有关,而1F-β-fructofuranosylnystose与卵巢癌风险降低有关.

科学领域:

营养科学营养科学
在瘤学瘤学.
微生物组研究微生物组研究

背景情况:

益生菌通过肠道微生物群调节,可能会影响雌激素代谢和与激素相关的癌症.
特定纤维类型的益生菌与妇科癌症风险之间的关系需要进一步研究.

研究的目的:

评估各种纤维类型益生菌的摄入量与患乳腺癌,子宫内膜癌和卵巢癌的风险之间的联系.
探索肠道微生物群调节在癌症发展中的潜在作用.

主要方法:

一项基于医院的病例控制研究,涉及2560例乳腺癌病例,454例子宫内膜癌病例和1031例卵巢癌病例 (1991-2006).
在食品中量化胰岛素类型的果糖,果糖-寡糖类 (尼斯托,克斯托,1F-β-果糖基尼斯托) 和银糖-寡糖类 (拉芬,葡萄糖).
使用食物频率问卷和食品含量实验室分析估计益生菌摄入量.
使用多重逻辑回归来推导几率比率 (OR) 和95%置信区间 (CI) 的统计分析.

主要成果:

尼斯托斯摄入量与乳腺癌 (OR=1.20),卵巢癌 (OR=1.39),子宫内膜癌 (OR=1.32) 的风险增加有边际直接关联.
高摄入的1F-β-fructofuranosylnystose与卵巢癌风险相反相关 (OR=0.67).
胰岛素类型的果实素,糖,拉芬糖和糖与三种研究癌症的风险没有显著关联.

结论:

大多数纤维类型益生菌的摄入量与乳腺,子宫内膜或卵巢癌风险没有一致或显著的关联.
像尼斯托斯和1F-β-fructofuranosylnystose这样的特定益生菌化合物可能对妇科癌症风险产生不同的影响,这需要进一步的研究.

关键词:

乳腺癌乳腺癌乳腺癌饮食饮食饮食饮食这是子宫内膜癌的癌症.卵巢癌是发生在卵巢的癌症.益生菌益生菌益生菌危险的风险危险的风险

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