相关实验视频

Updated: Jun 23, 2025

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Published on: December 13, 2015

激光介导解决方案:突破跨皮药物输送中的障碍

Ehsan Haghsay Khashechi¹, Abolfazl Afaghmehr¹, Niloofar Heidarizade²

¹Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran.

AAPS PharmSciTech

|June 19, 2024

概括

激光辅助药物递送 (LADD) 通过创建皮肤微通道以改善药物透来增强局部治疗. 虽然对皮肤状况有希望,但需要进一步的研究来优化技术和应对挑战.

科学领域:

皮肤病学皮肤病学
生物医学工程生物医学工程
制药科学制药科学

背景情况:

在皮肤疾病中,局部药物输送是首选的,但由于皮肤的屏障功能受到限制.
药物透到更深层的皮肤层仍然是传统局部治疗的重大挑战.
激光辅助药物递送 (LADD) 为克服这些局限性提供了一种新的方法.

研究的目的:

评估激光辅助药物递送 (LADD) 作为皮肤状况局部治疗的增强方法的潜力.
探索LADD如何改善通过皮肤自然屏障的药物透.
确定皮肤病学中LADD实施的挑战和未来研究方向.

主要方法:

使用激光,例如分数CO2,在皮肤中创建短暂的微通道.
促进治疗剂的沉积和强化透到皮肤和表皮层.
进行临床前和临床研究,以评估LADD的有效性和安全性.

主要成果:

在临床前和临床研究中,LADD在改善药物输送方面表现出有希望的结果.
激光的微通道创建显著提高药物透与传统的局部方法相比.
研究表明,LADD在治疗各种皮肤疾病,包括皮肤癌和痕等方面具有潜力.

结论:

激光辅助药物递送 (LADD) 是一种可行的策略,可以克服皮肤病学中的局部治疗局限性.
优化激光参数,药物配方和解决安全问题对于广泛采用LADD至关重要.
随着LADD技术的不断进步,它有可能彻底改变皮肤病治疗和患者护理.

关键词:

皮肤学皮肤学药物输送系统是药物输送系统.激光激光激光激光激光激光辅助的药物递送是激光辅助的药物递送.通过皮肤通过皮肤.

更多相关视频

An “All-laser” Endothelial Transplant

An “All-laser” Endothelial Transplant

Published on: July 6, 2015

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

相关概念视频

Drug Delivery: Miscellaneous Routes

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...

Non-Oral Extravascular Drug Absorption Routes

Non-Oral Extravascular Drug Absorption Routes

Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...

Drug Delivery: Parenteral Route

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

Routes of Drug Administration: Parenteral

Routes of Drug Administration: Parenteral

The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...

Drug Delivery: Enteral Route

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.