孕产妇的甲酸盐暴露和儿童的BMI轨迹 - - 一项18年出生队列随访研究
Hui-Ju Wen1,2, Pen-Hua Su3, Chien-Wen Sun2
1Institute of Earth Science, Academia Sinica, Taipei, Taiwan.
Journal of exposure science & environmental epidemiology
|June 19, 2024
概括
产前接触某些酸盐,如DEHP与儿童的长期肥胖有关. 母亲的尿甲酸代谢物与增加的BMI z分数和稳定的高BMI轨迹相关,直到18岁.
科学领域:
- 环境健康 环境健康
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
背景情况:
- 肥胖是一个全球性的健康危机,儿童的患病率越来越高.
- 酸盐可塑剂被怀疑是肥胖原体,但它们对早期暴露和长期肥胖的影响尚不清楚.
研究的目的:
- 调查产前甲酸盐暴露与儿童体重指数 (BMI) 模式之间的关联.
- 分析2岁至18岁的BMI轨迹,与孕期母亲的甲酸盐暴露有关.
主要方法:
- 在使用LC-MS/MS的母体尿液中量化了七种甲酸代谢物.
- 计算了儿童的BMI z分数,并使用轨迹分析来确定BMI模式.
- 使用通用估计方程 (GEE) 和后勤回归来评估酸盐-BMI关联.
主要成果:
- 孕产妇尿中的二甲基甲酸 (DEP) 代谢物与儿童 (2-18岁) 的BMI z得分增加相关.
- 双倍的母体尿mDEHP (DEHP的3个单基甲酸代谢物) 暴露增加了儿童保持稳定的高BMI轨迹的风险,直到18岁.
- 5岁后的BMI轨迹稳定,随着随访期间观察到显著的超重/肥胖率.
结论:
- 产前甲酸盐暴露与儿童的不良长期BMI轨迹有关.
- 特定的酸盐,如DEHP,可能在儿童肥胖的发育起源中发挥作用.
- 早期的甲酸盐暴露代表了预防儿童肥胖的潜在可修改的危险因素.
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