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癌症免疫疗法耐药性的机制,组合疗法和生物标志物

Manshi Yang¹, Mengying Cui¹, Yang Sun²

¹Department of Hepatobiliary and Pancreatic Surgery, The Second Hospital of Jilin University, Changchun, 130041, China.

Cell communication and signaling : CCS

|June 19, 2024

概括

像抗PD-1/PD-L1抗体这样的免疫检查点抑制剂 (ICI) 是有前途的,但却面临抗药性. 本综述探讨了抗药性机制和组合疗法,以提高癌症免疫疗法的疗效.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
药理学药理学是指药理学的学科.

背景情况:

反编程死亡1/编程死亡联体1 (抗PD-1/PD-L1) 抗体是癌症治疗的重要免疫检查点抑制剂 (ICI).
治疗耐药性限制了许多患者的抗PD-1/PD-L1疗法的有效性.
抵抗的机制包括瘤微环境中的因素,肠道微生物群和表观遗传调节.

研究的目的:

审查抗PD-1/PD-L1疗法的耐药性背后的机制.
探索各种联合治疗策略,以克服免疫疗法耐药性.
讨论用于预测耐药性和组合疗法疗效的生物标志物.

主要方法:

对抗PD-1/PD-L1耐药机制研究的文献综述.
对当前和新兴的免疫疗法组合疗法的分析.
对治疗反应的预测生物标志物的检查.

主要成果:

对抗PD-1/PD-L1治疗的耐药性与T细胞透,PD-1表达,干扰素信号,抗原呈现和脂质代谢有关.
涉及化疗,向治疗,传统中医,非编码RNA,其他ICI和癌症疫苗的组合策略是有希望的.
生物标志物对于预测耐药性和指导个性化组合策略至关重要.

结论:

了解抵抗机制是改善抗PD-1/PD-L1治疗结果的关键.
组合疗法提供了一种可行的方法来提高疗效和克服耐药性.
由生物标志物指导的个性化策略具有促进癌症免疫治疗的巨大潜力.

关键词:

生物标志物生物标志物癌症癌症癌症癌症组合疗法是一种联合疗法.免疫疗法耐药性免疫疗法耐药性机理机制机理机制

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