在接受抗瘤治疗的急性淋巴细胞白血病儿童的营养干预:系统性审查
Alan E Guzmán-León1, Jessica Avila-Prado1, Leslie R Bracamontes-Picos1
1Department of Chemical and Biological Sciences, Universidad de Sonora, Blvd. Luis Encinas y Rosales S/N, Hermosillo , 83000, Sonora, Mexico.
BMC nutrition
|June 19, 2024
概括
这一系统性审查发现,对于患有急性淋巴细胞白血病 (ALL) 的儿童的营养干预措施的高质量证据有限. 需要进行更严格的试验,以确定在接受治疗的儿科ALL患者的有效营养支持.
科学领域:
- 儿科瘤学 儿科瘤学
- 临床营养学 临床营养学
- 系统审查是系统的审查.
背景情况:
- 营养状况显著影响急性淋巴细胞白血病 (ALL) 患者的预后.
- 在低收入和中等收入国家,营养不良影响了大约50%的ALL儿童在诊断时.
- 抗瘤治疗可以加剧儿科ALL患者的营养物质耗尽.
研究的目的:
- 评估营养干预措施对被诊断患有ALL的正在接受治疗的儿童的影响.
- 综合来自随机对照试验对儿科ALL的营养支持的证据.
- 确定有关ALL营养干预措施的研究中的差距.
主要方法:
- 在多个数据库 (Cochrane CENTRAL, MEDLINE, EMBASE, LILACS, SciELO) 进行了系统的搜索.
- 纳入标准侧重于在接受积极治疗和营养干预的ALL儿童 (≤18岁) 随机对照试验.
- 研究选择,数据提取和偏差风险评估是由多名审稿人独立执行的.
主要成果:
- 25项研究符合纳入标准,其中18项研究指出存在偏差的高风险.
- 干预措施多种多样,包括化合物/食物,微量营养素和营养支持,在成分,剂量和持续时间方面具有显著的异质性.
- 关键的结果,如无脂肪质量,脂肪质量和总体水分,并没有得到一致的报道;然而,一些不良事件被记录下来.
结论:
- 目前关于ALL儿童营养干预措施的证据有限.
- 在这个人群中,急需进行高质量的随机对照试验.
- 未来的研究应该专注于标准化的结果和干预措施,以更好地指导临床实践.
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