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Updated: Jun 23, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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肝脏OATP1B区域分布:在PBPK框架内探讨的 rifampicin 中介药物相互作用的影响

Mattie Hartauer1, William A Murphy1, Kim L R Brouwer1

  • 1Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

CPT: pharmacometrics & systems pharmacology
|June 20, 2024
PubMed
概括

肝脏OATP1B载体分布显著影响药物相互作用的预测. 考虑到其不均性和诱导,可以提高药物相互作用的药理动力学模型的准确性.

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