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通过光热性能与基于团超分子框架的催化活动相协同的抗瘤疗法

Xinyu Wang¹, Jiajia Wang², Xiaoran Xu¹

¹Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Hubei Cancer Clinical Study Center & Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan 430071, China.

ACS applied materials & interfaces

|June 20, 2024

概括

无金属纳米材料在癌症治疗方面表现有前途. 研究人员开发了Methylene Blue/[closo-B12H12]2- (MB@B12H12) 用于化学动力学治疗和光热治疗,有效抑制黑色素瘤的生长.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
纳米技术纳米技术

背景情况:

化学动力学疗法 (CDT) 是一种有前途的癌症治疗策略,利用瘤特异性的化学反应.
非金属纳米材料为综合癌症诊断和治疗提供了低毒性和安全性等优势.
开发有效的,无金属的CDT剂对临床转化至关重要.

研究的目的:

通过使用染料修改集群来开发用于化学动力学治疗 (CDT) 的新型无金属化合物.
评估这些新型药物的化学动力学和光热治疗疗效,特别是甲蓝/[closo-B12H12]2- (MB@B12H12).
通过协同治疗作用来证明MB@B12H12的*体外*和*体内*抗黑色素瘤作用.

主要方法:

合成和表征无金属化合物通过将各种染料合到团的超分子框架.
在合成的非金属化合物中实验验证CDT活性.
使用理论计算,电子磁共振光谱和808nm光辐射来深入研究MB@B12H12,以确认光热和CDT特性.
评估MB@B12H12在抑制黑色素瘤细胞生长中的有效性 *in vitro* 和瘤生长 *in vivo*.

主要成果:

成功开发了一系列具有出色CDT活动的无金属化合物.
最优的化合物,甲蓝/[closo-B12H12]2- (MB@B12H12),显示出显著的光热性能和CDT活性.
通过联合光热和CDT效应,MB@B12H12有效地抑制了黑色素瘤的生长 *in vitro* 和 *in vivo*.
该研究证实了将配合染料与[closo-B12H12]2-用于制造强大的CDT试剂的概括性.

结论:

将染料合到[closo-B12H12]2-提供了一个多功能平台,用于开发有效的,无金属的化学动力学治疗剂.
MB@B12H12 具有针对黑色素瘤的协同光热和化学动力疗法的显著潜力.
这种方法具有相当大的临床翻译潜力,可以在癌症治疗中推进无金属CDT试剂.

关键词:

抗瘤疗法是一种抗瘤治疗.催化活动的催化活动.黑色素瘤是一种黑色素瘤.甲基蓝色/[克洛索-B12H12]2−2−在光热性能方面,光热性能非常好.

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