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重复刺激HPA轴对预先断奶奶奶牛皮质醇度,生长和行为的影响
Jessica Kern1, Matthew W Jorgensen2, Jacquelyn P Boerman1
1Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
Journal of animal science
|June 20, 2024
概括
用合成上皮质激素 (ACTH) 重复刺激下丘脑-垂体-上腺 (HPA) 轴会增加小牛的唾液皮质醇,但不会影响头发皮质醇,生长或行为.
科学领域:
- 兽医科学 兽医科学 兽医科学
- 内分泌学 在内分泌学.
- 动物行为 动物行为
背景情况:
- 下垂体-垂体-上腺 (HPA) 轴对于动物的应激反应至关重要.
- 头发皮质醇度是长期压力的生物标志物,而唾液皮质醇反映了急性压力.
- 了解HPA轴反应对于小牛的福利和管理至关重要.
研究的目的:
- 通过合成上腺皮质激素 (ACTH) 进行重复的HPA轴刺激对预先断奶奶牛的头发皮质醇,生长和行为的影响进行调查.
- 为了确定不同频率的ACTH刺激是否会影响这些参数.
主要方法:
- 27只霍尔斯坦小牛被分为控制,中度和频繁注射ACTH (Cosyntropin) 的组.
- 注射后测量了唾液皮质醇,并在基线,21日和49日分析了头发皮质醇.
- 每周使用加速度计监测小牛的生长 (体重,身高) 和行为 (躺时间).
主要成果:
- 与对照群相比,ACTH刺激显著增加了治疗小牛的唾液皮质醇度.
- 治疗组之间没有观察到头发皮质醇度,体重或躺时间的显著差异.
- 所有小牛的头发皮质醇度随着时间的推移而下降,无论治疗方式如何.
结论:
- 用Cosyntropin重复刺激HPA轴有效地提高了急性皮质醇水平 (唾液),但不会改变长期皮质醇 (头发),生长或年轻奶牛犊的行为.
- 这些发现表明,在这个年龄组中,响应HPA轴刺激时,急性和慢性压力标志物之间存在分离.
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