患有amnestic轻度认知障碍并伴有执行功能障碍的患者的情节性记忆网络特征
Chao Wang1, Rukun Cheng2, Wenhao Yang3
1Department of Radiology, Tianjin Baodi Hospital, Baodi Clinical College of Tianjin Medical University, Tianjin, China.
Brain and behavior
|June 20, 2024
概括
执行功能水平会影响轻度认知障碍患者的情节性记忆网络连接. 在aMCI患者中,较低的执行功能在左上旋中显示出功能连接的改变,影响记忆.
科学领域:
- 神经科学是一个神经科学.
- 认知神经学 认知神经学
- 神经成像是一种神经成像.
背景情况:
- Amnestic 轻度认知障碍 (aMCI) 的特点是记忆力缺陷.
- 执行功能 (EF) 在认知过程中起着至关重要的作用,包括记忆.
- 了解基于EF水平的aMCI的神经基础对于有针对性的干预至关重要.
研究的目的:
- 在aMCI患者的情节性记忆网络 (EMN) 中调查功能连接 (FC).
- 根据不同级别的执行职能 (EF) 来区分EMN FC特征.
- 探索EMN FC,认知表现和病理标记之间的关系.
主要方法:
- 来自阿尔茨海默氏病神经成像计划的76名参与者的分析 (23名健康对照,53名aMCI).
- 根据认知评估,将aMCI患者分为高EF和低EF组.
- 使用fMRI对EMN进行基于种子的FC分析,并收集认知和生物标志物数据.
主要成果:
- 与aMCI高EF组相比,aMCI低EF组表现出较差的认知功能,降低的葡萄糖代谢和更高的AV45水平.
- 在不同组的左上旋 (STG) 中发现了EMN FC的显著差异.
- 与健康对照组和aMCI高EF组相比,aMCI低EF组显示左侧STG FC增加;这与记忆回忆缺陷相关.
结论:
- 具有较低执行功能的aMCI在情节性记忆网络功能连接中呈现出明显的改变.
- 执行功能似乎调解了情节性记忆网络中的变化,影响了记忆性能.
- 左侧的STG功能连接可以作为一个生物标志物来区分基于EF的aMCI亚型.
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