肌素,囊素C,肌肉质量和死亡率:基于初级和复制人口的队列队列的发现
Dion Groothof1, Naser B N Shehab1, Nicole S Erler2,3
1Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Journal of cachexia, sarcopenia and muscle
|June 20, 2024
概括
血清肌素与肌肉质量有关,这质疑其用于估计功能的准确性. 血清囊素C与肌肉质量相关性较小,这表明它是功能和死亡风险的更可靠标志物.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 临床化学 临床化学
- 流行病学 流行病学
背景情况:
- 血清肌素是估计淋巴细胞过率 (eGFR) 的主要标志物.
- 建议在基于肌素的eGFR可能由于肌肉质量变化而不准确时进行血清囊素C的确认测试.
- 低肌肉质量是已知的过早死亡的风险因素,但肌素,囊素C,肌肉质量和死亡率之间的关系需要进一步研究.
研究的目的:
- 为了研究血清肌素和血清囊素C与肌肉质量之间的关联.
- 检查这些标记物与全因死亡率的关系.
- 评估血清肌素和血清囊素C的可靠性,作为与肌肉质量相关的功能和死亡风险指标.
主要方法:
- 分析了荷兰PREVEND研究中的8437名参与者和美国NHANES队列中的5033名参与者的数据.
- 使用线性回归来量化与肌肉质量替代物的关联.
- 考克斯比例危险回归被用来评估与死亡率的关联,缺失的数据通过多重归算处理.
主要成果:
- 较高的血清肌素与较大的肌肉质量相关,而血清囊素C没有显著的关联.
- 在相互调整后,血清肌素和肌肉质量之间的正相关性得到加强,血清肌素C和肌肉质量之间出现了反向关联.
- 这两种标志物都与死亡率有关;然而,经过调整后,较高的血清肌素表明死亡率下降,而血清细胞素C与死亡率增加的关联得到加强.
结论:
- 血清肌和肌肉质量之间强烈的关联引起了人们对估计GFR的可靠性的担忧.
- 血清囊素C与肌肉质量的关联很小,支持其在临床实践中作为更可靠的替代品的使用.
- 这些发现表明需要谨慎地解释基于肌素的eGFR,并强调囊素C在评估功能和死亡风险方面的潜力.
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