染色体层次的基因组组装和种群基因组学揭示了在 chieh-qua 中对子宫发育的关键选择
Min Wang1, Zhenqiang Cao1, Biao Jiang1
1Vegetable Research Institute, Guangdong Academy of Agricultural Sciences, Guangdong Key Laboratory for New Technology Research of Vegetables, Guangzhou 510640, China.
Horticulture research
|June 20, 2024
概括
这项研究介绍了首个染色体水平的基因组组合 chieh-qua,揭示了其与瓜和更大的遗传多样性的密切关系. 这一资源有助于理解化 chieh-qua 和识别 subgynoecy 的基因.
科学领域:
- 基因组学就是基因组学.
- 植物科学 植物科学
- 进化生物学 进化生物学
背景情况:
- 瓜在亚洲是一个重要的菜作物,但它的遗传基础和化仍然不太清楚.
- 了解 chieh-qua 的遗传基础对于作物改良和进化研究至关重要.
研究的目的:
- 为 chieh-qua.生成高质量的染色体水平参考基因组组合.
- 为了研究瓜和瓜之间的进化关系.
- 探索遗传多样性,并识别与重要的特征相关的基因,如subgynoecy.
主要方法:
- 使用PacBio长读和Illumina短读的混合组装策略.
- 基因预测和重复序列的分析.
- 比较基因组学,人口基因组学和全基因组协会研究 (GWAS).
主要成果:
- 产生了953.3 Mb的染色体级基因组组合,其中包含24,593个蛋白质编码基因.
- 瓜与瓜有着密切的进化关系,但具有更高的遗传多样性.
- GWAS确定了subgynoecy的QTLs,MYB59在subgynoecious品种中显示差异性表达.
结论:
- 这项研究为 chieh-qua 研究提供了宝贵的基因组资源,并对其化的洞察力.
- 这些发现促进了分子繁殖的努力,并更深入地了解了虫的进化.
- 鉴定MYB59提供了一个潜在的目标,用于育种subgynoecious chieh-qua品种.
相关概念视频
The Ratio of X Chromosome to Autosomes
8.5K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
8.5K
Meiosis I
40.5K
Meiosis is the division of a diploid cell into haploid cells forming sperm and eggs in animals through differentiation. Meiosis I is the first stage of meiosis, where the genetic recombination of homologous chromosomes and the reduction of the ploidy level by half occurs.
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
40.5K
X and Y Chromosomes
25.9K
Among mammals, the gender of an organism is determined by the sex chromosomes. Humans have two sex chromosomes, X and Y. Every human diploid cell has 22 pairs of autosomes and one pair of sex chromosomes. A human female has two X chromosomes, while a male has one X chromosome and one Y chromosome.
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
25.9K
Nondisjunction
3.8K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers. Nondisjunction is common during anaphase I or anaphase II of meiosis. Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
3.8K
Lampbrush Chromosomes
7.9K
In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops...
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops...
7.9K
Cis-regulatory Sequences
9.8K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
9.8K


