阴道微生物群与女性不孕症期间的体外受精有关
Tao Wang1, Penghao Li2, Xue Bai3,4
1Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy Chengdu University Chengdu China.
iMeta
|June 20, 2024
概括
适度的阴道乳酸菌对怀孕和体外受精 (IVF) 结果有益. 最佳的乳酸菌水平,大约80%,提高怀孕率与较高或较低的水平相比.
科学领域:
- 生殖医学 生殖医学
- 微生物组研究 微生物组研究
- 遗传学和基因组学 遗传学和基因组学
背景情况:
- 阴道微生物群对女性生殖健康至关重要.
- 不孕率的增加需要了解微生物组在生育和试管婴儿中的作用.
- 之前的研究表明,乳酸菌的重要性,但最优的丰度怀孕是不清楚的.
研究的目的:
- 调查阴道微生物组组成与接受生育治疗的女性生殖结果之间的关联.
- 为成功怀孕和体外受精 (IVF) 确定乳酸菌种的最佳丰度.
主要方法:
- 来自1411个人的阴道样本的16SrRNA测序,包括1255个经历胚胎移植的人.
- 临床和生化数据的收集.
- 对71个样本进行了元基因组分析,以确定功能差异.
主要成果:
- 适度丰富的乳酸菌 (~80%),特别是L. crispatus和L. iners,与高丰富 (>90%) (44.81%-51.06%) 相比,与更高的怀孕率 (54.35%-57.73%) 有关.
- 社区状态类型 (CST) IV-B,与中度的Gardnerella vaginalis和更高的Lactobacillus,显示了可比的怀孕率.
- 不怀孕的妇女有更多的抗生素耐药基因,主要是蛋白质细菌和菌菌.
结论:
- 最佳的阴道乳酸菌丰度对于成功怀孕和试管婴儿的结果至关重要.
- 阴道微生物组分析可能有助于检测不孕症和个性化试管婴儿治疗策略.
- 进一步研究特定微生物群落和抗生素耐药性基因的功能作用是有必要的.
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