优糖酸性酸性和乳酸性酸性与美特福林毒性相关
Feras Al-Moussally1, Jung-Jung Tien2, Kanya Rajagopalan2
1Department of Internal Medicine, University of Central Florida College of Medicine, Kissimmee, USA.
Cureus
|June 20, 2024
概括
甲福明的毒性会导致乳酸和酸,即使血糖水平正常. 这种情况,美特福林相关的乳酸酸和euglycemic ketoacidosis (MALKA),需要在急性损伤患者中高度临床怀疑.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床毒理学 临床毒理学
背景情况:
- 糖尿病酸性酸症 (DKA) 是已知的糖尿病并发症.
- 与急性功能衰竭相关的甲胺毒性通常会导致乳酸化.
- 甲胺诱导的euglycemic ketoacidosis (MALKA) 的理解较少.
研究的目的:
- 报告一例甲福明毒性病例,该病例既有乳酸性酸症,也有症.
- 为了突出诊断的挑战的甲胺诱导的euglycemic酸性酸症.
- 强调在特定的临床场景中考虑甲胺毒性的重要性.
主要方法:
- 一个患有甲福明毒性,急性功能衰竭,乳酸和症的病人的病例报告.
- 最初的表现被硫氨酸尿素诱导的低血糖症所混.
- 临床评估的重点是确定甲胺相关的乳酸性酸性疾病 (MALA) 和甲胺相关的乳酸性酸性疾病与euglycemic ketoacidosis (MALKA).
主要成果:
- 患者呈现出复杂的代谢图片,包括乳酸和症.
- 最初的表现模仿了低血糖,使诊断复杂化.
- 甲胺毒性被确定为急性功能衰竭的潜在原因.
结论:
- 甲胺相关的乳酸化与euglycemic ketoacidosis (MALKA) 是一个未被认可的疾病.
- 在使用甲胺,急性功能衰竭和euglycemia的患者中,对MALA和MALKA的高度怀疑指数是合理的.
- 迅速识别和管理甲胺毒性至关重要.
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