氧化平衡得分,全身炎症反应指数和心血管疾病风险之间的关联:基于NHANES 2007-2018数据的横截面分析
Kai Chen1,2,3, Senlin Li1,2,3, Zhipeng Xie1,2,3
1School of Medicine, South China University of Technology, Guangzhou, Guangdong, China.
Frontiers in nutrition
|June 20, 2024
概括
这项研究发现,更高的氧化平衡评分 (OBS),包括饮食和生活方式,与较低的炎症标志物系统免疫炎症指数 (SII) 和系统炎症反应指数 (SIRI) 有关. 这表明OBS可能会降低心血管疾病的风险.
科学领域:
- 研究氧化应激,炎症和心血管健康的交叉点.
- 使用大规模的国家卫生调查数据进行可靠的分析.
- 采用先进的统计方法,包括回归和支线分析.
背景情况:
- 系统性氧化应激 (SOS) 和炎症指数之间的关系存在有限的研究.
- 心血管疾病 (CVD) 患病率是一个重大的公共卫生问题.
- 系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI) 等炎症标志物与心血管疾病有关.
研究的目的:
- 检查氧化平衡指数 (OBS) 与心血管疾病 (CVD) 患病率之间的关联.
- 通过不同水平的炎症指数 (SII和SIRI) 调查这种关联.
- 区分饮食OBS与生活方式OBS对心血管疾病风险因素的影响.
主要方法:
- 采用了2007-2018年国家健康和营养检查调查 (NHANES) 9,451名参与者的数据.
- 从20个饮食和生活方式因素计算出整体OBS.
- 采用加权线性回归分析 (WLRA),物流回归分析 (LRA),灵敏度分析 (SA) 和受限制立方支线 (RCS) 分析.
主要成果:
- 总体而言,OBS与SII和SIRI都有显著的负相关性.
- 更高的生活方式OBS与冠状动脉疾病 (CAD),高血压,充血性心力衰竭 (CHF),心肌梗塞 (MI) 和中风的发病率降低有关.
- 在OBS (整体和饮食) 和炎症指数 (CHF的SIRI,MI的SII) 之间观察到显著的相互作用.
结论:
- 氧化平衡评分 (OBS),包括饮食和生活方式组成部分,与全身炎症标志物 (SII和SIRI) 有负相关性.
- 更高的生活方式OBS与较低患主要心血管疾病的风险有关.
- 这些发现突出了调节饮食和生活方式因素的潜力,以控制炎症和降低心血管疾病风险.
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