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Updated: Jun 23, 2025

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使用Ga-FAPI-LM3 PET进行早期肺纤维化疾病的增强检测

Jianhao Chen^1,2,3, Doudou Luo², Yaqing Dai²

¹Department of Nuclear Medicine and Minnan PET Center, Xiamen Cancer Center, Xiamen Key Laboratory of Radiation Oncology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361003, China.

Molecular pharmaceutics

|June 20, 2024

概括

这项研究介绍了Ga-FAPI-LM3,一种用于早期肺纤维化检测的新型分子探针. 探测器显示,与单体标志物相比,纤维化肺组织的吸收率显著更高,提供了更好的非侵入性诊断潜力.

科学领域:

医疗成像医学成像
放射化学放射化学是指辐射化学.
肺部医学肺部医学

背景情况:

早期检测肺纤维化仍然是一个重大的临床挑战.
纤维细胞激活蛋白 (FAP) 和体静止素受体2 (SSTR2) 在纤维化肺组织中被上调.
需要新的分子探针来进行非侵入性早期诊断.

研究的目的:

评估Ga-FAPI-LM3的有效性,一种异体双价分子探针,用于早期检测肺纤维化.
为了比较Ga-FAPI-LM3的诊断性能与单体标记剂Ga-FAPI-46和Ga-DOTA-LM3.

主要方法:

建立了白素诱导的早期肺纤维化小鼠模型.
在人类和小鼠肺组织中量化了FAP和SSTR2表达,使用西式涂抹,qPCR和免疫光.
通过小动物PET成像合成和评估Ga标记的单质和异质双价探针.

主要成果:

在纤维化肺组织中观察到FAP和SSTR2的显著上调.
在纤维化肺组织中,Ga-FAPI-LM3的吸收量明显高于正常组织和单体标志物.
佩特成像显示,使用异性双价位探针对纤维化病变的视觉检测优越.

结论:

Ga-FAPI-LM3是一种有前途的分子成像剂,用于早期,非侵入性检测肺纤维化.
由于协同准,异体双价探针提供了比单体标记剂更好的诊断性能.
这一策略为精确的肺纤维化早期诊断提供了新的途径.

关键词:

在FAPI-LM3中使用.纤维细胞激活蛋白质是什么分子成像分子成像技术肺部纤维化肺部纤维化索马托斯坦因子受体2

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