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Updated: Jun 30, 2026

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在蛋白质聚合过程中微粘度的提奥夫拉T─a记者:α-Synuclein的研究案例

Konstantin Rusakov1, Aadil El-Turabi2, Lasse Reimer3

  • 1Faculty of Construction and Environmental Engineering, Warsaw University of Life Sciences, 02-776 Warsaw, Poland.

The journal of physical chemistry letters
|June 20, 2024
PubMed
概括

激光光谱学有效地检测早期蛋白质寡合体,这对于了解帕金森病至关重要. 这种先进的技术可以在α-synuclein聚合过程中监测微度的变化.

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相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...