相关实验视频
Updated: Jun 23, 2025

08:40
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
7.1K
与微观结肠炎的长期临床结果相关的因素
Yusuke Miyatani1, Yuga Komaki1,2, Fukiko Komaki1,2
1Inflammatory Bowel Disease Center, University of Chicago Medicine, Chicago, IL, USA.
Annals of medicine
|June 20, 2024
概括
对布索尼德的良好反应和实现组织学缓解是显微性结肠炎患者长期临床缓解的关键. 组织学缓解允许患者在不需要药物的情况下保持缓解.
科学领域:
- 胃肠病学 胃肠病学
- 内部医学 内部医学
背景情况:
- 微观性结肠炎是慢性腹的日益公认的原因.
- 了解与疾病相关的因素和治疗方法对于管理微观结肠炎的结果至关重要.
研究的目的:
- 描述疾病相关因素和治疗对微观结肠炎临床结果的作用.
- 在微观结肠炎患者中确定临床和组织学缓解的预测因素.
主要方法:
- 2010年8月至2016年5月期间接受治疗的微观结肠炎患者医疗记录的回顾性审查.
- 用单变量和多变量分析评估患者特征和治疗方法作为临床结果的预测指标.
- 临床缓解的定义是缺乏症状,组织学缓解是缺乏炎症.
主要成果:
- 在72名患者中,54.3%实现了临床缓解. 布德索尼德反应 (p=.0002) 和组织学缓解 (p=.0008) 与临床缓解有关.
- 多变量分析显示,布索尼德的反应 (p=.0052) 显著预测了临床缓解 (OR 25.00).
- 所有组织学缓解的患者在没有药物治疗的情况下都保持了临床缓解,与持久炎症患者不同 (p=.0002).
结论:
- 对布索尼德的有利反应与微观大肠炎的长期临床缓解有显著的关联.
- 实现组织学缓解使患者能够在没有进一步的医疗治疗的情况下保持临床缓解.
- 需要进行更大规模的研究来证实这些关于微观结肠炎管理的发现.
相关概念视频
Chronic Bowel Disorders: Introduction
440
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
440
Inflammatory Bowel Disease I: Ulcerative Colitis
161
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
161
Inflammatory Bowel Disease II: Crohn's Disease
213
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
213
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331
Inflammatory Bowel Disease V: Surgical Management
139
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
139

