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Updated: Jun 23, 2025

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells
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Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells

Published on: April 9, 2018

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直接的GPCR-EGFR相互作用使膜与核之间的协同信息传输成为可能

Michael Gekle1, Robert Eckenstaler2, Heike Braun2

  • 1Julius-Bernstein-Institute of Physiology, Martin Luther University Halle-Wittenberg, 06112, Halle (Saale), Germany. michael.gekle@medizin-halle.de.

Cellular and molecular life sciences : CMLS
|June 20, 2024
PubMed
概括

表皮生长因子受体 (EGFR) 与G蛋白合受体 (GPCR) 的异构化对于协同核信号传输至关重要. 这项研究表明,AT1R-EGFR相互作用能够实现协同的基因表达调节,超出了简单的依赖连接体的激活.

关键词:
在AT1R中,它是AT1R.ангиотензин II 受体 1 型欧洲农业基金会 (EGFR) 是一个.皮肤表皮生长因子受体.异构化是一种异构化.血清反应因子的血清反应因子.

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