用 phytic 酸修饰的酸水泥的生物和机械性能
Valentin C Steinacker1, Jan Weichhold2, Tobias Renner3
1Department of Oral & Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070, Würzburg, Germany. steinacker_v@ukw.de.
Journal of materials science. Materials in medicine
|June 20, 2024
概括
植物酸 (IP6) 提高了酸水泥的性能和生物相容性,为骨再生应用提供了比酸更好的替代品.
科学领域:
- 生物材料科学 生物材料科学
- 材料科学 材料科学 材料科学
- 生物化学 生物化学
背景情况:
- 酸水泥 (CPC) 需要设置延迟器才能进行最佳加工.
- 酸是一种常见的减速剂,具有较差的生物相容性.
- 植物酸 (IP6) 是一种新兴的CPCs的替代设置减速剂.
研究的目的:
- 研究具有IP6.6不同度的CPCs的物理和生物特性.
- 为了比较IP6修饰的CPC与参考材料的细胞相容性和降解.
- 评估IP6作为骨增强应用中的设置减速剂的潜力.
主要方法:
- 制备不同IP6度的布鲁希特和缺乏的酸 (CDHA) 水泥.
- 压力强度和物理性能的评估.
- 在体外细胞相容性测试使用骨质细胞 (MG-63) 和骨质细胞 (RAW 264.7) 细胞.
- 评估水泥降解和再吸收率.
主要成果:
- IP6增强了布鲁希特水泥 (11.2 MPa与9.8 MPa) 和CDHA水泥 (27.0 MPa与21.2 MPa) 的压力强度.
- 与基准细胞相比,IP6显著改善了细胞兼容性,细胞活动和数量增加了多达11倍.
- 较低的IP6剂量更有效,IP6增加了水泥降解和再吸收.
- IP6显示出比酸更好的生物相容性.
结论:
- 植物酸 (IP6) 是酸水泥的一个有前途的化阻滞剂,增强了其物理和生物性能.
- 与酸相比,IP6提供了优越的细胞兼容性和降解概况.
- 修改为IP6的CPC具有骨增强和骨科应用的潜力.
相关概念视频
Hydration of Cement
220
Hydration of cement is a chemical reaction between cement particles and water. This process occurs primarily through two mechanisms: through-solution and topochemical. In the through-solution process, anhydrous compounds dissolve into their constituents, hydrates form in the solution, and then precipitate from the supersaturated solution. The topochemical process involves solid-state reactions at the cement particle surface. The through-solution process dominates the topochemical process at the...
220
Essential Minerals for Bone Health
3.9K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
3.9K
Sulfate Attack on Concrete
133
Sulfate attack on concrete is a deterioration process characterized by a whitish discoloration beginning at the edges and corners, accompanied by cracking and spalling. This phenomenon occurs when sulfates react with the components of hardened concrete, forming compounds like calcium sulfate and calcium sulfoaluminate which occupy more space than the substances they replace, causing the concrete to expand and disrupt.
Sulfates from sources like soil, groundwater, or industrial effluents...
Sulfates from sources like soil, groundwater, or industrial effluents...
133
Soundness of Cement
158
The soundness of cement refers to the ability of cement paste to retain its volume after setting. Unsound cement can lead to expansion and structural damage due to the presence of free lime, magnesia, and calcium sulfate. Free lime hydrates very slowly, expanding and causing unsoundness, which is difficult to detect because it intercrystallizes with other compounds. Magnesia also reacts with water, forming crystals that can disrupt the cement's structure. Calcium sulfate can create...
158


