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手术前的蛋白尿与因细胞癌的部分腎切除术后的功能相关

Michele Nicolazzini¹, Carlotta Palumbo¹, Francesca Porté¹

¹Division of Urology, Department of Translational Medicine, University of Eastern Piedmont, Maggiore Della Carità Hospital, Corso Mazzini 18, 28100, Novara, Italy.

World journal of urology

|June 20, 2024

概括

术前蛋白尿与部分切除术 (PN) 后12个月内功能下降有关. 然而,基线估计的膜过率 (eGFR) 是PN后长期功能的唯一独立预测指标.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
泌尿器科泌尿器科泌尿器科泌尿器科
在瘤学瘤学.

背景情况:

术前蛋白尿是慢性病 (CKD) 的已知预后因素.
在部分切除术 (PN) 后评估功能对于患者的治疗结果至关重要.
了解PN后功能恶化的预测因素对于手术规划和患者管理至关重要.

研究的目的:

评估术前蛋白尿和部分切除术 (PN) 后的功能之间的关联.
在患有恶性质的患者中确定PN后短期和长期功能预测因素.

主要方法:

在2000年至2021年期间,对单个恶性质进行PN的患者进行了回顾性评估.
包括手术前可用的蛋白尿病数据的患者.
分析基线特征,估计的淋巴细胞过率 (eGFR) 变化和后勤回归模型,以预测12个月和最后一次随访后的CKD第三阶段或更高阶段.

主要成果:

包括295名患者;22人患有手术前蛋白尿症.
两组之间在年龄,吸烟状况,高血压,糖尿病,瘤大小或缺血症使用方面没有发现显著差异.
蛋白尿症患者的基线CKD-III的比率更高. 随访时间中位数为46.5个月,研究小组之间没有观察到新的CKD-III或eGFR下降的差异.
单变量分析确定了手术前蛋白尿,年龄和基线eGFR作为12个月后CKD-III的预测因素. 在最后一次随访时,年龄和基线eGFR预测CKD-III.
多变量逻辑回归分析揭示了基线eGFR作为CKD-III的唯一独立预测因素,无论是在12个月和最后的随访时.

结论:

基线eGFR是PN后长期功能唯一独立的预测指标.
手术前的蛋白尿与经过PN的12个月后的功能相关.
在PN之前对蛋白尿的评估可以帮助确定在第一年内患功能恶化的风险较高的患者.

关键词:

瘤,细胞癌,细胞癌.慢性脏疾病慢性脏疾病部分切除术部分切除术蛋白质尿症是一种蛋白质尿症.功能功能功能

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