当前管理的desmoid瘤:一个审查
Bernd Kasper1, Elizabeth H Baldini2, Sylvie Bonvalot3
1Sarcoma Unit, Mannheim Cancer Center (MCC), Mannheim University Medical Center, University of Heidelberg, Mannheim, Germany.
JAMA oncology
|June 20, 2024
概括
更新的desmoid瘤 (DT) 管理指南强调向更少侵入性的策略转变,并纳入新的医疗药物. 精心选择治疗对于优化瘤控制和瘤瘤患者的生活质量至关重要.
科学领域:
- 在瘤学瘤学.
- 罕见的癌症 罕见的癌症
- 纤维细胞瘤 纤维细胞瘤
背景情况:
- 德斯莫伊德瘤 (DT) 是一种罕见的,局部具有侵略性的纤维细胞增殖,具有不可预测的行为.
- 从历史上看,手术是主要的治疗方法,但现在偏爱的方法是不那么侵入性.
- 需要更新关于DT管理的全球共识指南.
研究的目的:
- 更新2020年全球基于证据的共识指南,用于管理瘤.
- 纳入当地的疗法和新型医疗剂的最新进展.
- 在国际临床医生中协调治疗策略.
主要方法:
- 召开了90多名国际瘤专家,患者和倡导者的共识会议.
- 在MEDLINE和Embase进行了相关随机临床试验 (RCT) 的文献搜索.
- 专注于全身疗法,局部废除疗法和手术指示.
主要成果:
- 2023年指南更新包括局部废除疗法,如冷疗法和手术的新指示.
- 包含关于g-分泌酶抑制剂的数据,其中nirogacestat被确定为第一个批准用于DT的药物.
- 强调基于患者因素的多学科瘤板和个性化治疗选择.
结论:
- 治疗瘤的治疗选择正在扩大.
- 管理需要仔细考虑DT症状,风险,位置,疾病和患者偏好.
- 优化瘤控制和生活质量需要个性化治疗策略.
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