在COVID-19大流行期间产前母亲的心理痛苦和新生儿的大脑发育
Susan Weiner1,2, Yao Wu1, Kushal Kapse1
1Developing Brain Institute, Children's National Hospital, Washington, DC.
JAMA network open
|June 20, 2024
概括
在COVID-19大流行期间,增加的母亲心理痛苦与新生儿的大脑体积较小有关,特别是在白质,海马和杏仁体. 这突显了母亲的压力对婴儿大脑发育的影响.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 公共卫生 公共卫生
背景情况:
- 在怀孕期间增加母亲的心理压力可能会对胎儿大脑发育产生负面影响.
- 在COVID-19大流行期间,产前母亲的心理痛苦显著增加.
研究的目的:
- 为了调查COVID-19大流行,增加母亲的心理痛苦和新生儿的大脑生长之间的关联.
- 使用定量3D体积磁共振成像 (MRI) 进行精确的大脑体积测量.
主要方法:
- 前性横截面研究,比较COVID-19大流行之前 (2014-2019) 和期间 (2020-2022) 的母婴二合体.
- 通过国家特征焦虑清单和感知压力尺度评估母亲的心理健康;进行新生儿大脑MRI.
- 普通最小平方线性回归分析了区域大脑体积差异,调整了混因素.
主要成果:
- 流行病队伍报告了显著更高的焦虑和压力得分.
- 患有高危情绪的母亲的婴儿表现出白质减少,右海马和左桃体体积减少.
- 提升的特征焦虑独立与左桃体体积的减少相关,即使在控制了流行病影响之后.
结论:
- 产前母亲的心理痛苦与新生儿的区域大脑体积变化有关.
- 这些发现强调了母亲压力的神经发育影响,特别是在COVID-19大流行期间加剧.
- 这项研究强调了孕妇心理健康支持的重要性.
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