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更年期和脂肪质量对喘炎炎症的影响
Anastasia Papaporfyriou1, Kostas Bartziokas2, Eftychia Papachatzopoulou3
1Division of Pulmonology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
肥胖可能通过降低IL5和IL17水平来预防喘. 女性激素具有复杂的作用,雌激素抑制炎症,雄激素与喘炎症标志物有混合相关性.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
背景情况:
- 喘受女性荷尔蒙和肥胖的影响,影响炎症过程.
- 了解这些相互作用对于治疗女性喘至关重要.
研究的目的:
- 研究性激素,肥胖和喘女性炎症标志物之间的关系.
- 阐明雌激素和雄激素在喘发病过程中的特定作用.
主要方法:
- 测量了11-18名患有喘的绝经前和绝经后妇女的性激素 (FSH,LH,雌激素,雌激素,,,Δ4安德罗) 和血清细胞因子 (IL1β,IL13,IL17a,IL-5,IL6,TNF-a).
- 在月经周期和更年期状态的不同阶段分析了激素水平和炎症标志物之间的相关性.
主要成果:
- 绝经前正常体重的女性比肥胖女性有更高的IL5和IL17a水平.
- 在绝经前的妇女中,安德罗二与IL1β呈正相关性,而雌激醇和TNF-a与IL1β和丸激素呈负相关性.
- 在绝经后的女性中,TNF-a与FSH呈负相关性,但与丸激素呈正相关性;IL10与雌激醇呈正相关性.
结论:
- 肥胖似乎通过抑制IL5和IL17对喘有保护作用.
- 雌激素可以抑制Th1和Th2的炎症,而雄激素在喘相关的炎症中表现出双重作用.
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