人类大脑结构-功能合的空间和时间模式与发展联系在一起.
Guozheng Feng1,2,3, Yiwen Wang1,2,3, Weijie Huang1,2,3
1State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
eLife
|June 20, 2024
概括
大脑连接,或结构和功能连接体 (SC-FC) 合,在不同区域发展不均. 这种发展会影响一般智力,并与特定的基因通路有关.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 在Connectomics上,我们提供了连接.
背景情况:
- 大脑的结构电路支着功能同步,这对认知至关重要.
- 结构和功能连接体 (SC-FC) 合的发育轨迹及其与认知和基因表达的关系尚不清楚.
研究的目的:
- 通过青春期来描述SC-FC合的发展.
- 调查SC-FC合和一般情报之间的关系.
- 探索SC-FC合开发和转录组架构之间的关联.
主要方法:
- 利用了439名参与者的多式磁共振成像数据 (年龄为5.7-21.9岁).
- 预测的功能连接使用皮质内和皮质外结构连接来定义SC-FC合.
- 分析了SC-FC合的发育变化,其对一般智力的预测,以及与基因通路的相关性.
主要成果:
- 在视觉和体力运动网络中,SC-FC合最强,与髓含量和功能梯度相关.
- 发展导致异质的SC-FC合增加,特别是在体力运动,前双相,背部注意力和默认模式网络的皮质区域.
- SC-FC 合显著预测了一般智力,特别是在前端对象和默认模式网络中,并显示了与寡细胞和星球细胞相关基因的关联.
结论:
- 在SC-FC合中,大脑网络之间呈现出不同的发育模式.
- SC-FC合成熟与一般智力等认知能力有关.
- 基因表达在寡细胞和星球细胞通路中影响了SC-FC合的发育轨迹.
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