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Updated: Jun 23, 2025

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TTK 抑制剂 OSU13 通过激活瘤 STING 来促进免疫治疗反应

Vijaya Bharti1,2,3, Amrendra Kumar1,2,3, Yinchong Wang1,2,3,4

  • 1Department of Pathology.

JCI insight
|June 20, 2024
PubMed
概括

TTK抑制剂OSU13通过诱导细胞循环停止和DNA损伤,激活cGAS/STING通路,表现出抗瘤作用. 将OSU13与免疫疗法结合起来,可以增强STING专业的癌症的抗瘤活性和存活率.

关键词:
癌症免疫疗法癌症免疫疗法细胞应激压力是细胞的压力.化学因子 (chemokines) 是一种化学物质.在瘤学瘤学.

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