人类一生中的形态度大脑组织显示了与认知表现相关的分散性增加
Jiao Li1,2, Chao Zhang1,2, Yao Meng1,2
1The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
PLoS biology
|June 20, 2024
概括
大脑网络组织随着年龄的增长而发生变化,影响认知灵活性. 这项研究揭示了大脑结构连接在整个生命周期中如何演变,为衰老和执行功能提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 认知科学 认知科学
背景情况:
- 人类大脑在一生中表现出复杂的分离和整合模式.
- 了解大脑组织的终身变化对于认知健康至关重要.
- 皮层多元组提供了一种新的方法,用于在梯度空间中绘制大脑组织图.
研究的目的:
- 通过使用形态相似性网络 (MSN) 调查大脑网络分离和整合的与年龄相关的变化.
- 探索这些变化如何与人类一生中的认知灵活性和执行功能有关.
主要方法:
- 利用了1790名健康个体 (8-89岁) 的结构磁共振成像 (MRI).
- 分析了与年龄相关的全球,网络内部和网络之间的分散在3D多元体内.
- 构建的形态相似性网络 (MSN) 作为个体大脑的"指纹".
主要成果:
- 全球大脑组织轨迹反映了分子模式,如乙胆受体分布.
- 大脑群体随着年龄的增长而呈现出更多的分散,这表明了更多的不同类型的相似性概况.
- 运动和关联皮层中扩散的增加调解了年龄对认知灵活性的影响.
- 二级感官皮层变得不那么分散,这表明3D多重体的位置转移.
结论:
- 揭示了多维梯度空间中的形态相似性网络 (MSN) 的与年龄相关的分离和集成.
- 提供了关于大脑形态特征的寿命变化及其对认知的影响的新见解.
- 突出了从发育到衰老的大脑网络组织的动态性质.
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