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相关概念视频

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

2.7K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.5K
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

5.1K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.1K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

1.8K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
1.8K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

3.2K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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相关实验视频

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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

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维生素D和甲状腺功能:一个门德尔的随机化研究.

Nikolina Pleić1, Mirjana Babić Leko1, Ivana Gunjača1

  • 1Department of Medical Biology, University of Split, School of Medicine, Split, Croatia.

PloS one
|June 20, 2024
PubMed
概括

更高的维生素D水平可能会降低高甲状腺刺激激素 (TSH) 和自身免疫性甲状腺功能低下症的风险. 这项研究调查了维生素D和甲状腺功能指标之间的因果关系.

科学领域:

  • 内分泌学 在内分泌学.
  • 遗传学 遗传学 是一个
  • 营养科学 营养科学

背景情况:

  • 维生素D对于正常的器官功能至关重要,包括甲状腺.
  • 低血清25-氧维生素D [25(OH) D]与甲状腺疾病有关,但因果关系尚不确定.
  • 门德尔随机化 (MR) 可以探索维生素D和甲状腺健康之间的因果关系.

研究的目的:

  • 为了研究血清25(OH) D度对甲状腺功能指标的因果作用.
  • 为了确定维生素D状态是否会影响甲状腺激素水平和自身免疫性甲状腺疾病.

主要方法:

  • 进行了两样本的门德尔随机化 (MR) 分析.
  • 利用大规模的全基因组关联研究 (GWAS) 数据用于25(OH) D,TSH,ft4,ft3,TT3,TPOAb和自身免疫性甲状腺疾病.
  • 采用逆方差加权 (IVW) 作为主要方法,使用加权模式,加权中位数,MR-Egger,MR-PRESSO和CAUSE进行灵敏度分析.

主要成果:

  • 观察到25(OH) D对高TSH的诱导性逆因果作用 (25(OH) D的1SD增加与高TSH风险降低12%相关).
  • 发现了25(OH) D对自身免疫性甲状腺功能低下症的暗示性逆因果作用 (25(OH) D的SD增加与16.34%的较低风险相关).

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  • 没有发现维生素D对其他甲状腺参数的显著因果影响.

    • 结论:

    • 较高的基因预测维生素D度与高TSH和自身免疫性甲状腺功能低下的风险降低有关.
    • 这些发现表明,维生素D在特定的甲状腺疾病中具有潜在的保护作用.
    • 血清中维生素D度似乎没有对其他测量的甲状腺参数产生因果影响.