上下脑回路用于操作性心
Airi Yoshimoto1, Shota Morikawa2, Eriko Kato1
1Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.
概括
通过生物反,老鼠学会了自愿控制心率,从而实现了显著的心率降低和持续的益处,如减少焦虑. 这种心肌梗塞涉及从前带皮层到心脏的特定神经通路.
科学领域:
- 神经科学
- 行为生物学
- 生理学
背景情况:
- 通过实时反,可以自愿调节心率.
- 了解HR控制的神经机制对于治疗干预至关重要.
研究的目的:
- 在小鼠模型中使用生物反来研究自愿心率降低的神经回路.
- 确定HR生物反训练对行为和生理学的长期影响.
主要方法:
- 通过新皮层刺激和中枢前脑束刺激来获得实时HR反.
- 神经通路操纵涉及到向腹中质核 (VMT) 投射的前带皮层 (ACC) 神经元的失活以及该通路的节律刺激.
- 生理和行为评估包括HR监测,抗焦虑行为测试和血红细胞计数.
主要成果:
- 在生物反训练的5天内,大鼠的HR减少了大约50%.
- 在训练后至少持续了10天,并与焦虑症行为和红细胞数量的增加有关.
- 禁用ACC-VMT通路可以防止心肌梗塞,而泰达节律刺激可以复制心肌梗塞,突显了该通路的关键作用.
结论:
- ACC-VMT神经通路对于通过生物反调解自愿心率降低至关重要.
- 这种途径通过投射到背中垂体和随后的模糊核来影响心率,控制了副交感输出.
- HR生物反训练会诱导持久的生理和行为变化,这表明在涉及自主失调的疾病中可能有治疗应用.
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