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燃烧产生的污染物与巴尔干半岛低洪水受影响地区的脏疾病有关

Wanlin Guo¹, Hong Ching Kwok¹, Stephen M Griffith²

¹Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.

Environmental science & technology

|June 20, 2024

概括

塞尔维亚燃烧木材和煤炭的燃烧污染物污染了土壤和小麦,显著增加了巴尔干地区特有病 (BEN) 的风险. 这些污染物增强脏细胞中的阿里斯托洛希酸DNA损伤,使它们与BEN发育有关.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
腎臟病學 (nephrology) 是一種醫學.

背景情况:

巴尔干地区特有病 (BEN) 影响了南欧成千上万的人,与*Aristolochia clematitis**摄入的阿里斯托洛希酸 (AA) 有关.
之前的研究确定了辅助因子,但与地理梯度相比,发现BEN的贡献很小.

研究的目的:

调查燃烧产生的污染物作为巴尔干地区特有病 (BEN) 的潜在致病因素.
为了确定来自生物质和燃煤的污染物是否会增加阿里斯托洛希酸 (AA) 诱导的毒性.

主要方法:

来自塞尔维亚BEN特有地区和非特有地区的土壤和小麦样本的气体染色体质谱学 (GC-MS) 选.
使用培养细胞的同时暴露研究,以评估对AA诱导的DNA adduct形成的污染物影响.

主要成果:

生物质燃烧衍生毛和燃煤衍生在BEN特有地区的土壤中显著增加 (高达63倍和14倍).
这些污染物还在来自特有地区的小麦谷物中发现了更高的度.
同时暴露的研究表明,这些污染物增强了AA诱导的细胞中的DNA adduct形成.

结论:

燃烧产生的污染物,特别是furfural和中链,被确定为可能导致BEN的因素.
巴尔干半岛燃烧生物质和煤炭的广泛做法,加上AA暴露,可能会促进BEN的发展.
这些发现凸显了环境污染物在病流行中的作用.

关键词:

巴尔干半岛特有性脏病.多变量分析多变量分析.不针对性分析的分析分析分析.

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