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Updated: Jun 23, 2025

Purification of Ubiquitinated p53 Proteins from Mammalian Cells
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USP11通过调节p53-p21轴通过MDM2二氧化化调节线粒的进展和衰老

Won-Joo Kim1, Abdul Basit1, Jae-Ho Lee1

  • 1Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 443-721, South Korea; Department of Biomedical Sciences, The Graduate School, Ajou University, Suwon, 443-721, South Korea.

Biochemical and biophysical research communications
|June 20, 2024
PubMed
概括

在癌症中过度表达的削弱USP11,通过稳定p53蛋白质来抑制细胞增殖. 这种机制涉及USP11调节MDM2,为结直肠和乳腺癌提供潜在的治疗点.

关键词:
细胞循环停止 细胞循环停止蛋白质的稳定性 蛋白质的稳定性衰老是一种衰老.USP11 美国 美国在p2121中,在 p53 里,p53 是一个 p53 的类型.

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