酸盐涂层的纳米颗粒作为瓜中瓜维诺酸B的潜在输送载体:分子相互作用和封装特性
Haoning Yang1, Yu Mu1, Dan Zheng1
1Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang 110819, PR China; Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang 110819, PR China.
Food chemistry
|June 20, 2024
概括
瓜酸B (GUB) 是瓜中一种抗氧化剂,它是利用蛋白制成纳米颗粒的. 这些GUB-zein-NaCas纳米粒子增强了GUB.
科学领域:
- 食品科学 食品科学 食品科学
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
背景情况:
- 瓜维诺B (GUB) 具有显著的抗氧化特性,但其水溶性较差,限制了其应用.
- 胺的一种胺,表现出自我组装的能力,使其成为生物活性化合物输送的潜在矩阵.
研究的目的:
- 为了研究瓜维诺酸B (GUB) 和 zein.之间的相互作用.
- 开发和表征瓜维诺B载-甲酸盐纳米颗粒 (GUB-Z-N NP).
- 为了评估制造的纳米粒子的抗氧化活性和稳定性.
主要方法:
- 使用光谱方法 (光,FTIR) 和计算分析来研究GUB-zein相互作用.
- 纳米粒子是使用抗溶剂共沉降方法制造的.
- 评估了粒子大小,封装效率,再分散性,稳定性和抗氧化活性.
主要成果:
- GUB通过静态火,涉及范德瓦尔斯,结合和疏水力与zien相互作用.
- GUB-Z-N NPs在200nm以下的大小中成功合成,显示出良好的封装和重新分散性.
- 与自由GUB相比,纳米颗粒表现出对环境因素的增强稳定性和优越的抗氧化活性.
结论:
- 齐宁作为一个有效的矩阵封装瓜维诺B (GUB).
- 基于Zain的纳米粒子为改善GUB的可溶性和抗氧化疗效提供了一个有前途的输送系统.
- 这些发现支持GUB-Z-N NP在食品工业中的潜在使用.
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