一个具有不对称的椎腰部布局的脊柱电路模型控制了四足动物的向后运动和抓伤
Qinghua Zhu1, Fang Han1, Ying Yu2
1College of Information Science and Technology, Donghua University, Shanghai, 201620, China.
概括
这项研究模拟了脊柱回路,用于向后移动和抓伤,揭示了不对称的椎组织. 该模型解释了脊髓网络如何产生各种运动行为,如走路,慢跑和抓.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 发动机控制器的控制器
背景情况:
- 前进运动的脊柱电路已经得到了很好的研究,但后向运动和伤机制仍然不清楚.
- 了解这些基本运动功能对于动物的生存和神经学研究至关重要.
研究的目的:
- 提出和研究脊柱回路的计算模型,用于向后移动和抓伤.
- 探索不对称的宫腰部组织和特定内部神经元在产生各种运动行为中的作用.
主要方法:
- 达纳等人对现有模型的扩展,达纳等人. 整合一个不对称的椎脊柱电路布局.
- 模拟不同的控制策略,包括上驱动和 afferent反,以重现实验数据.
- 在V0D和V0V commissural interneuron deletion条件下对模型输出的分析.
主要成果:
- 该模型成功地复制了四足运动 (步行,,半身,束) 和 (单侧和双侧) 的实验数据.
- 删除V0V commissural内部神经元导致半束的运动和同步的双边后肢.
- 删除V0D和V0V commissural内部神经元导致了受束的运动.
- 该模型在组合驱动下在向后双脚脊柱 (BBS) 运动中产生了各种后肢协调模式.
结论:
- 脊柱电路表现出宫和腰部区域对特定节奏四肢运动的不对称招募.
- 一个单一的脊柱网络可以通过通过脊柱上输入或体感反进行重新配置来支持多种运动行为.
- 拟议的模型为脊髓组织和复杂的节奏运动的神经控制提供了新的见解.
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