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Updated: Jun 23, 2025

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
07:23

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通过限制PKCα的S-化,S-化氨减少酶减轻了对吗啡止痛药的耐受性

Ling-Yan Su1, Lijin Jiao2, Qianjin Liu3

  • 1Key Laboratory of Genetic Evolution and Animal Models of the Chinese Academy of Sciences, Yunnan Key Laboratory of Animal Models and Human Disease Mechanisms, and KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650204, China; College of Food Science and Technology, and Yunnan Key Laboratory of Precision Nutrition and Personalized Food Manufacturing, Yunnan Agricultural University, Kunming, Yunnan, 650201, China.

Redox biology
|June 20, 2024
PubMed
概括

S-尼特氨酸氨基缩酶 (GSNOR) 在对吗啡的耐受性方面发挥着关键作用. 降低GSNOR水平通过增加蛋白S-化和抑制蛋白激酶α (PKCα) 来降低吗啡耐受性.

关键词:
止痛药的耐受性 止痛药的耐受性这就是GSNOR.吗啡是一种吗啡.这是一种PKCα.在S-化中.

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