相关实验视频

Updated: Jun 23, 2025

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration

Published on: June 15, 2018

皮质刺激强度-持续时间常数异常在肌缩侧硬化症中的异常

Nathan A Pavey¹, Parvathi Menon¹, Angel V Peterchev²

¹Brain and Nerve Research Centre, Concord Clinical School, University of Sydney, Concord Hospital, Sydney, Australia.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

|June 20, 2024

概括

皮质强度-持续时间常数 (SDTC) 降低在肌缩侧面硬化症 (ALS) 患者与疾病严重程度和认知障碍相关,这表明ALS发病过程中通道活性增加.

科学领域:

神经科学是一个神经科学.
神经学神经学
生物物理学的生物物理.

背景情况:

强度-持续时间常数 (SDTC) 标志着神经元刺激性,受过时 (Na+) 导电量的影响.
在肌缩侧面硬化症 (ALS) 中研究皮质SDTC可能会揭示疾病机制的洞察力.

研究的目的:

为了确定皮质SDTC是否在ALS患者中异常.
调查皮层SDTC和ALS发病,疾病进展和认知状态之间的关联.

主要方法:

在17名ALS患者中,用可控制脉冲参数跨磁刺激 (cTMS) 来测量皮层SDTC和基.
休息运动值 (RMTs) 在各种脉冲宽度 (30-120μs) 中被评估,主要的运动皮层上有一个八的线圈.

主要成果:

与对照组相比,ALS患者的皮质SDTC显著减少 (150.58 ± 9.98 μs与205.94 ± 13.7 μs相比,P < 0.01).
减少SDTC与更快的疾病进展相关,较低的ALS功能评分尺度-修订 (ALSFRS-R) 评分,以及更长的疾病持续时间.
在患有认知异常的患者中观察到更大的SDTC减少,这是通过异常的爱丁堡认知ALS查得分表明的.

结论:

皮层SDTC减少与更具侵略性的ALS表型和认知障碍有关.
过渡性Na+电导率的增加是导致SDTC和ALS发病率降低的潜在机制.

关键词:

肌缩侧面硬化症 (Amyotrophic Lateral Sclerosis) 是一种肌缩侧面硬化症.可控制的横性磁刺激发动机唤起了潜在的潜力.强度持续时间常数的时间常数.

更多相关视频

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation

Published on: September 23, 2017

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

相关概念视频

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.