梅毒感染是宫性阴道HPV发生的危险因素吗? 一个病例控制研究研究
Napoleão Moura Dias Neto1, Vanessa Gonçalves Nunes Moura Dias2, Denise Maria Christofolini3
1Postgraduate Program of Health Sciences, Centro Universitário FMABC, Santo André, SP, Brazil.
Journal of infection and public health
|June 20, 2024
概括
梅毒和人类乳头瘤病毒 (HPV) 的同时感染并没有增加女性的HPV患病率或宫病变严重程度. 这项研究没有发现任何证据表明梅毒会恶化与HPV相关的宫变化.
科学领域:
- 妇科 妇科医生 妇科
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 梅毒和人类乳头瘤病毒 (HPV) 是常见的性传播感染 (STIs),不成比例地影响类似风险组的女性.
- 了解这些感染之间的相互作用对于有效的查和管理策略至关重要.
研究的目的:
- 为了确定HPV在患有梅毒和没有梅毒的妇女中的患病率.
- 在共感染的情况下,鉴别与HPV相关的宫病变.
- 探索与梅毒和HPV共感染相关的社会人口学因素.
主要方法:
- 一项涉及176名妇女的病例控制研究 (88名梅毒患者,88名没有),按年龄配对.
- 使用混合捕获测试来诊断HPV存在和亚型.
- 细胞病理学分析评估了宫病变的严重程度,包括非典型状细胞 (ASC-US,ASC-H) 和高度内皮病变 (HSIL).
主要成果:
- 在患有梅毒 (14.8%) 和没有梅毒 (18.1%) 的女性中,HPV的患病率相似.
- 非典型的状细胞 (ASC-US,ASC-H) 和高度内皮病变 (HSIL) 主要观察到患有高风险HPV的女性,特别是那些同时感染的女性.
- 在梅毒和对照组之间没有发现细胞异型的显著差异.
结论:
- 梅毒感染似乎不会增加女性HPV的患病率.
- 与梅毒的同时感染似乎不会加剧前体宫癌病变的存在或严重性.
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