流行病学趋势和与脑髓母细胞瘤患者的存活相关的因素:一项为期45年的基于人口的回顾性研究
Dongjie He1, Yahui Yang2, Peiwen Wu3
1Department of Radiation Oncology, Air Force Medical University Tangdu Hospital, Xi'an, China.
概括
脑髓母细胞瘤 (MB) 发病率稳定,但患病率正在上升. 化疗在高风险的MB患者中改善了生存率,突出了关键的预后因素.
科学领域:
- 神经瘤学神经瘤学
- 流行病学 流行病学
- 癌症研究 癌症研究
背景情况:
- 骨髓母细胞瘤 (MB) 是一种主要的大脑瘤,具有有限的最新流行病学数据和长期结果信息.
- 了解MB发病率,流行率和治疗的当前趋势对于公共卫生规划和患者护理至关重要.
研究的目的:
- 分析最新的流行病学数据和使用基于人口的数据集来分析脑髓母细胞瘤 (MB) 的长期结果.
- 为了确定MB发病率,流行率和治疗方式的趋势.
- 确定影响MB患者总生存 (OS) 和癌症特异性生存 (CSS) 的预后因素.
主要方法:
- 利用来自监测,流行病学和最终结果 (SEER) 数据库的临床和流行病学数据.
- 采用Joinpoint回归模型来分析发病率,流行率和治疗趋势.
- 应用Cox危险和竞争风险模型来评估生存结果 (OS和CSS).
主要成果:
- 到2019年,MB发病率保持稳定,在每10万人口中为0.15;男性发病率呈现上升趋势.
- 观察到20年限期患病率的显著增加,从1999年的0.00016%增加到2018年的0.00203%.
- 多变量分析确定了年龄,诊断年份,组织学,阶段,手术和放射治疗作为显著的预后因素. 化疗使用与高风险群体的更好的生存相关.
结论:
- 脑膜母细胞瘤的发病率稳定,而其患病率显著增加.
- 这项研究确定了脑髓母细胞瘤的关键预后因素.
- 化疗在高风险脑髓母细胞瘤患者群体中表现出良好的预后,这表明它在治疗策略中的重要性.
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