年龄改变了严重睡眠呼吸暂停和全因死亡率之间的关联
Amin Ramezani1, Mehrnaz Azarian1, Amir Sharafkhaneh2
1Center for Innovations in Quality, Effectiveness, and Safety, Michael E. DeBakey VA Medical Center, Houston, TX, USA; Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Sleep medicine
|June 20, 2024
概括
严重的睡眠呼吸暂停 (SA) 在老年人中更为常见,但其与死亡率的关联随着年龄的增长而减少. 这表明SA可能减少了对老年人群的有害影响.
科学领域:
- 老年学是一门学科.
- 睡眠医学 睡眠医学
- 流行病学 流行病学
背景情况:
- 睡眠呼吸暂停 (SA) 的患病率随着年龄的增长而增加,但其对不同年龄组的健康结果的影响仍然不清楚.
- 了解SA与死亡率相关的年龄相关差异对于公共卫生至关重要.
- 需要大规模的纵向数据来调查这些关联.
研究的目的:
- 评估不同年龄组睡眠呼吸暂停 (SA) 严重程度与全因死亡率之间的关联.
- 确定年龄如何改变SA和死亡风险之间的关系.
- 分析与睡眠呼吸暂停严重程度相关的死亡率数据,针对年轻人,中年人和老年人.
主要方法:
- 一个自然语言处理管道从睡眠研究的解释中提取了呼吸暂停-呼吸暂停指数 (AHI).
- 参与者被分为没有SA (AHI<5) 和严重SA (AHI≥30) 组.
- 队列被分为年龄组 (年轻人≤40,中年40-65岁,老年人≥65岁),并根据共变量调整分析死亡率.
主要成果:
- 在一个由146,148名参与者组成的队列中,严重的SA患病率随年龄增加.
- 总的来说,严重的SA与较低的全因死亡率相关 (aOR为0.56).
- 严重的SA与死亡率的保护性关联随着年龄的增长而减少,在老年人中变得不那么明显 (年轻人:aOR 1.11;中年人:aOR 0.64;老年人:aOR 0.44).
结论:
- 严重的睡眠呼吸暂停患病率随着年龄的增长而增加,但其与死亡风险降低的关联在老年人中减少.
- 这些发现表明,睡眠呼吸暂停可能对老年人死亡率的影响不那么严重.
- 建议进一步进行因果分析,以探索睡眠呼吸暂停,衰老和全因死亡率之间的相互作用.
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